Table 2.
Baseline characteristics of participants in VITAL-CVD case-control substudy.
| VITAL-CVD | Controls | Cases | P-value† |
|---|---|---|---|
| N | 741 | 741 | |
| Age (years) * | 69.5 (65.6, 74.9) | 70.2 (65.7, 76.2) | 1.7e-1 |
| Women (%) | 40.9 | 40.9 | 1.0 |
| White (%) | 87.2 | 88.5 | 1.0 |
| Current smokers (%) | 4.4 | 8.3 | 5.3e-3 |
| BMI (kg/m2) * | 26.6 (24.1, 30.1) | 27.4 (24.4, 31.0) | 8.0e-3 |
| BMI categories | 3.4e-1 | ||
| < 25 kg/m2 (%) | 33.5 | 27.8 | |
| 25 to 29.9 kg/m2 (%) | 41.1 | 42.2 | |
| ≥ 30 kg/m2 (%) | 25.4 | 30.0 | |
| HDL-C (mg/dL) * | 50.0 (39.0, 63.0) | 46.0 (38.0, 59.0) | 3.7e-4 |
| LDL-C (mg/dL) * | 123.0 (101.2, 145.0) | 119.0 (97.0, 145.0) | 2.7e-1 |
| Total-C (mg/dL) * | 202.0 (176.0, 228.0) | 196.0 (171.0, 227.0) | 1.3e-1 |
| Triglycerides (mg/dL) * | 113.0 (86.5, 158.0) | 121.0 (92.0, 177.0) | 7.0e-3 |
| hs-CRP (mg/L) *‡ | 1.7 (0.9, 3.9) | 2.1 (1.1, 5.3) | 1.5e-1 |
| Main study intervention assignment (%) | 48.9 | 51.0 | 2.0e-3 |
| Physical activity * | 14.6 (4.3, 30.0) | 12.9 (3.0, 28.0) | 4.1e-1 |
*
Median (IQR).
†
P-value for statistical test comparing controls vs. cases.
‡
Data available only for 97 cases and 89 controls.
Abbreviations: BMI – body mass index; LDL-C – low density lipoprotein cholesterol; HDL-C – high density lipoprotein cholesterol; Total-C – total cholesterol; hs-CRP – high-sensitivity C-reactive protein.