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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: Eur J Cell Biol. 2022 Jun 1;101(3):151244. doi: 10.1016/j.ejcb.2022.151244

Figure 1. WASP-family protein domain structure and cellular function.

Figure 1.

Schematic showing domain organization of different WASP-family proteins found in mammals (left) and their main functions and localizations in the cell (right). Domain structures are drawn to scale. Based on the structural homology from AlphaFold 2 prediction shown in Figure 5, we re-define WHAMM and JMY N-terminal domain as WJHD (WHAMM and JMY homology domain). WH1: WASP homology 1; GBD: GTPase binding domain; PRR: proline-rich region; WCA: WH2-central-acidic domain; WHD: WAVE homology domain; WAHD: WASH homology domain; LIR: LC3-interacting region; WJHD: WHAMM and JMY homology domain; J-loop: JMY-specific loop; CC: coiled coil domain; NLS: nuclear localization signal; WHDL: WAVE homology domain-like. “++” indicates positively charged sequence.