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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Exp Physiol. 2022 Jun 17;107(8):994–1006. doi: 10.1113/EP090341

Figure 4.

Figure 4.

Middle cerebral arteries (MCA) reactivity assessed with ex vivo pressure myography. MCA dilation responses to increasing concentration of sodium nitroprusside (SNP). Dose response curve reflects data corresponding to number of (D)ays after an exposure to either (A) Ecig (n=7) or (B) 3R4F Reference Cigarette (n=4) and compared to responses in controls (Air, n=5). Numeral notation in panel A & B indicates post hoc testing with significant difference (p<0.05) between Air vs Day 0 = “0”, Air vs Day 1 = “1”. (C) Summary graph showing maximal response to SNP (i.e., [10−4] data point from dose response curves in A & B) showing no difference in overall time course to vessel recovery between Ecig and 3R4F Cigarette. * signifies different compared to Air (p<0.05). Post-hoc testing also revealed no differences between respective Ecig and 3R4F Cigarette groups at any time point. Mean±SD.