FIGURE 1.

Percentage of mediation by biomarkers on hospitalization for heart failure. HR (95% CI) for the unweighted prespecified HHF. ^†First change from baseline measurement. ^‡Weighted average of change from baseline from all post‐baseline measurements. Mediators in blue were associated with decreases in placebo‐adjusted changes from baseline with ertugliflozin; mediators in red were associated with increases in placebo‐adjusted changes from baseline. ALT, alanine aminotransferase; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; HDL‐C, high‐density lipoprotein cholesterol; HHF, hospitalization for heart failure; HR, hazard ratio; SBP, systolic blood pressure; UACR, urine albumin‐to‐creatinine ratio