FIGURE 2.

Percentage of mediation by biomarkers on a prespecified exploratory kidney composite outcome. HR (95% CI) for the unweighted prespecified exploratory kidney composite outcome comprising sustained 40% decrease from baseline in estimated glomerular filtration rate, chronic kidney replacement therapy, or kidney death was 0.66 (0.50‐0.88). ^†First change from baseline measurement. ^‡Weighted average of change from baseline from all post‐baseline measurements. Mediators in blue were associated with decreases in placebo‐adjusted changes from baseline with ertugliflozin; mediators in red were associated with increases in placebo‐adjusted changes from baseline. HbA1c, glycated haemoglobin; HDL‐C, high‐density lipoprotein cholesterol; HR, hazard ratio; RBC, red blood cell; SBP, systolic blood pressure