TABLE 2.

Summary of multivariable mediation analyses of hospitalization for heart failure and composite kidney outcome using forward selection approaches

Time point	HHF			Composite kidney outcome
	Mediator (by adding factors sequentially by larger % mediation)	% Mediation	(95% CI)	Mediator (by adding factors sequentially by larger % mediation)	% Mediation	(95% CI)
Early change	ALB, CL, HCT, HDL‐C, log (UACR), urate, protein	83	(22.81, 303.30)	HbA1c, HCT, urate	118	(47.43, 405.81)
Weighted average change	ALB, urate, haemoglobin	110	(43.48, 378.78)	Haemoglobin, urate	121	(51.49, 422.62)

Abbreviations: ALB, albumin; CL, chloride; HbA1c, glycated haemoglobin; HCT, haematocrit; HDL‐C, high‐density lipoprotein cholesterol; HHF, hospitalization for heart failure; UACR, urine albumin‐to‐creatinine ratio.