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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Exp Neurol. 2022 Jun 30;356:114158. doi: 10.1016/j.expneurol.2022.114158

Figure 2.

Figure 2.

Schematic representation of derivation of the BXD recombinant inbred mouse strains. Panel A shows the derivation of the original 40 strains from an F2 intercross between C57Bl/6J (black strain) and DBA/2J (grey strain) mice. The two strains differ by more than 6 million variations in DNA and derivation from F2 maintains many genetic linkages and thus challenges gene mapping precision. Panel B helps to remedy the situation by breaking up linkages via advanced intercrosses and thus improving mapping precision. Reproduced and modified from Ashbrook and others (2021)