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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Nat Genet. 2022 Jul 14;54(8):1202–1213. doi: 10.1038/s41588-022-01119-7

Extended Data Fig. 5. YAP activation causes regional DNA demethylation in enhancers.

Extended Data Fig. 5

a, Pie charts showing the distribution of methylation peaks and YAP-induced rDMRs to mm10 mouse genomic features. b, Average peak profile of methylation peaks and YAP-induced rDMRs mapped to nearest TSS. Note the disassociation of YAP-induced rDMRs from TSS. c, The de novo motif analysis of YAP-induced rDMRs. Both RUNX and TEAD recognition motifs were identified in the top 10 enriched motifs. d, e, Enrichment profiles representing the TEAD motif centered at YAP-induced rDMRs (d) and TET1 peaks (e). f, Enrichment profiles representing the TET1, TEAD4 and H3K27ac ChIP-seq reads centered at YAP-induced rDMRs.