Table 3.
Proteins with the largest umbilical vein-to-artery differences in relative abundance.
| A. Proteins with Higher Relative Abundance in the Umbilical Vein | | ||||
| Target Full Name | UniProt | % Difference (CI) | P-value | Adjusted P-value |
| Netrin receptor UNC5D | Q6UXZ4 | 2004 (407, 8637) | 0.0006 | 0.0111 |
| Ephrin-B2 | P52799 | 1837 (335, 8531) | 0.0011 | 0.0111 |
| SLIT and NTRK-like protein 5 | O94991 | 1534 (286, 6813) | 0.0013 | 0.0111 |
| Osteopontin | P10451 | 1375 (262, 5909) | 0.0014 | 0.0111 |
| Leucine-rich repeat transmembrane protein FLRT3 | Q9NZU0 | 844 (182, 3058) | 0.0018 | 0.0111 |
| Collectin-12 | Q5KU26 | 787 (202, 2504) | 0.001 | 0.0111 |
| Properdin | P27918 | 692 (164, 2280) | 0.0016 | 0.0111 |
| Cystatin-D | P28325 | 662 (195, 1872) | 0.0006 | 0.0111 |
| Nucleoside diphosphate kinase B | P22392 | 663 (217, 1735) | 0.0003 | 0.0111 |
| Thyroid Stimulating Hormone | P01215.P01222 | 629 (174, 1837) | 0.0009 | 0.0111 |
| Growth factor receptor-bound protein 2 | P62993 | 562 (169, 1529) | 0.0007 | 0.0111 |
| Brother of CDO | Q9BWV1 | 560 (153, 1625) | 0.0012 | 0.0111 |
| Granulocyte colony-stimulating factor | P09919 | 551 (147, 1616) | 0.0014 | 0.0111 |
| Semaphorin-6A | Q9H2E6 | 531 (149, 1500) | 0.0011 | 0.0111 |
| Importin subunit beta-1 | Q14974 | 528 (142, 1528) | 0.0014 | 0.0111 |
| Adapter molecule crk | P46108 | 520 (144, 1475) | 0.0012 | 0.0111 |
| Inorganic pyrophosphatase | Q15181 | 521 (139, 1508) | 0.0014 | 0.0111 |
| Xaa-Pro aminopeptidase 1 | Q9NQW7 | 513 (168, 1304) | 0.0005 | 0.0111 |
| B. Proteins with Lower Relative Abundance in the Umbilical Vein | ||||
| Target Full Name | UniProt | % Difference (CI) | P-value | Adjusted P-value |
| GTP-binding nuclear protein Ran | P62826 | −93 (−98, −76) | 0.0006 | 0.0111 |
| 40S ribosomal protein S3 | P23396 | −83 (−94, −50) | 0.0041 | 0.0128 |
| 6-phosphogluconate dehydrogenase, decarboxylating | P52209 | −76 (−89, −48) | 0.0019 | 0.0111 |
| Peroxiredoxin-6 | P30041 | −71 (−85, −44) | 0.0016 | 0.0111 |
| Platelet factor 4 | P02776 | −71 (−90, −17) | 0.0255 | 0.0465 |
| Histone H1.2 | P16403 | −70 (−89, −18) | 0.0229 | 0.0431 |
| DNA topoisomerase 1 | P11387 | −69 (−86, −35) | 0.0051 | 0.0146 |
| Protein S100-A6 | P06703 | −68 (−82, −41) | 0.0016 | 0.0111 |
| Aflatoxin B1 aldehyde reductase member 2 | O43488 | −67 (−82, −41) | 0.0015 | 0.0111 |
| Ubiquitin-conjugating enzyme E2 N | P61088 | −67 (−82, −39) | 0.0021 | 0.0111 |
| Peroxiredoxin-1 | Q06830 | −66 (−81, −39) | 0.002 | 0.0111 |
| Ubiquitin+1, truncated mutation for UbB | P62979 | −66 (−81, −39) | 0.0017 | 0.0111 |
| Histone acetyltransferase type B catalytic subunit | O14929 | −66 (−83, −32) | 0.0058 | 0.0159 |
| Non-histone chromosomal protein HMG-14 | P05114 | −65 (−84, −27) | 0.0093 | 0.0216 |
| Casein kinase II 2-alpha:2-beta heterotetramer | P68400.P67870 | −65 (−80, −37) | 0.0021 | 0.0111 |
Proteins significantly increased in relative abundance by ≥500% (A) or significantly decreased by ≥65% (B) following multiple comparisons with adjusted p-value of ≤0.05 when comparing venous cord blood to arterial cord blood in neonates ≤ 32 weeks of gestation (N=12) using the SomaLogic platform. CI, Confidence Interval