Table 4.

Proteins with the largest neonatal-to-umbilical vein blood differences in relative abundance.

A. Proteins with Lower Relative Abundance in the Neonatal Blood as Compared to the Umbilical Vein
Target Full Name	UniProt	% Difference	P-value	Adjusted P-value
Human Chorionic Gonadotropin	P01215.P01233	−96 (−97, −92)	<0.0001	<0.0001
Annexin A1	P04083	−82 (−90, −66)	<0.0001	0.0002
Nucleoside diphosphate kinase B	P22392	−81 (−92, −54)	0.0007	0.0071
Thyroid Stimulating Hormone	P01215.P01222	−78 (−90, −53)	0.0004	0.0044
Granulocyte colony-stimulating factor	P09919	−73 (−89, −34)	0.0061	0.0353
Annexin A2	P07355	−71 (−83, −49)	0.0001	0.0017
Chorionic somatomammotropin hormone	P0DML2.P0DML3	−69 (−79, −54)	<0.0001	0.0001
Plasminogen activator inhibitor 1	P05121	−67 (−84, −31)	0.0046	0.0278
Mitogen-activated protein kinase 8	P45983	−63 (−72, −51)	<0.0001	<0.0001
Inosine-5’-monophosphate dehydrogenase 1	P20839	−61 (−72, −47)	<0.0001	0.0001
Activated Protein C	P04070	−59 (−71, −42)	<0.0001	0.0004
Fibroblast growth factor 1	P05230	−56 (−67, −41)	<0.0001	0.0001
Dynein light chain roadblock-type 1	Q9NP97	−55 (−70, −33)	0.0004	0.0046
Fibroblast growth factor 23	Q9GZV9	−55 (−73, −24)	0.0044	0.027
Tyrosine-protein kinase Lyn, isoform B	P07948	−55 (−73, −26)	0.0029	0.0197
Vesicular integral-membrane protein VIP36	Q12907	−55 (−62, −46)	<0.0001	<0.0001
Insulin-like growth factor-binding protein 1	P08833	−55 (−72, −25)	0.0031	0.0207
R-spondin-3	Q9BXY4	−54 (−66, −38)	<0.0001	0.0004
Thrombin	P00734	−54 (−71, −27)	0.002	0.0148
Adenylosuccinate lyase	P30566	−53 (−72, −23)	0.0048	0.0294
Glutathione S-transferase P	P09211	−52 (−70, −23)	0.0041	0.0259
Protein FAM3B	P58499	−52 (−61, −41)	<0.0001	<0.0001
Tyrosine-protein kinase Fer	P16591	−52 (−72, −18)	0.0099	0.0489
Phosphoglycerate kinase 1	P00558	−51 (−70, −18)	0.0082	0.0425
Interleukin-23	P29460.Q9NPF7	−50 (−69, −19)	0.0069	0.038
B. Proteins with Higher Relative Abundance in Neonatal Blood as Compared to the Umbilical Vein
Target Full Name	UniProt	% Difference	P-value	Adjusted P-value
Trefoil factor 1	P04155	482 (286, 782)	<0.0001	<0.0001
Serum amyloid P-component	P02743	403 (261, 596)	<0.0001	<0.0001
C-reactive protein	P02741	363 (143, 782)	0.0001	0.001
Protein-glutamine gamma-glutamyltransferase E	Q08188	338 (123, 751)	0.0001	0.0018
Complement component C9	P02748	281 (128, 536)	<0.0001	0.0004
Troponin I, fast skeletal muscle	P48788	218 (88, 439)	0.0001	0.0018
Ectonucleoside triphosphate diphosphohydrolase 5	O75356	203 (151, 263)	<0.0001	<0.0001
Midkine	P21741	203 (77, 421)	0.0003	0.0036
Integrin alpha-IIb: beta-3 complex	P08514.P05106	168 (99, 258)	<0.0001	<0.0001
Interleukin-17 receptor B	Q9NRM6	166 (114, 227)	<0.0001	<0.0001
Eotaxin	P51671	160 (92, 253)	<0.0001	<0.0001
C-X-C motif chemokine 13	O43927	153 (91, 236)	<0.0001	<0.0001
Interleukin-1 receptor-like 1	Q01638	148 (60, 281)	0.0002	0.0031
Alpha-1-antichymotrypsin complex	P01011	131 (74, 210)	<0.0001	0.0001
Troponin T, cardiac muscle	P45379	131 (80, 199)	<0.0001	<0.0001
Bone sialoprotein 2	P21815	130 (48, 256)	0.0007	0.0065
Phospholipase A2, membrane associated	P14555	128 (53, 243)	0.0003	0.0039
C-C motif chemokine 28	Q9NRJ3	123 (79, 179)	<0.0001	<0.0001
Peptide YY	P10082	123 (72, 189)	<0.0001	0.0001
Collagenase 3	P45452	122 (44, 239)	0.0008	0.0074
Lymphocyte activation gene 3 protein	P18627	120 (65, 197)	<0.0001	0.0002
Kallikrein-7	P49862	119 (73, 177)	<0.0001	<0.0001
Parathyroid hormone	P01270	116 (61, 189)	<0.0001	0.0003
Alpha-1 -antichymotrypsin	P01011	108 (65, 166)	<0.0001	0.0001

Proteins significantly decreased in relative abundance by ≥50% (A) or increased by ≥100% (B) following multiple comparisons with adjusted p-value of ≤0.05 when comparing neonatal blood to venous cord blood in neonates ≤ 32 weeks of gestation (N=25) using the SomaLogic platform. CI, Confidence Interval