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. 2022 Jul 8;14(7):e26660. doi: 10.7759/cureus.26660

Figure 3. Spike protein RBD sequence alignment and manual identification of amino acid differences.

Figure 3

The green font indicates residues included in the receptor-binding domain. The yellow highlights demonstrate the amino acid changes identified between SARS-CoV and MERS-CoV. Green highlights demonstrate the amino acid changes identified between SARS-CoV and SARS-CoV-2. Pink highlights demonstrate the same amino acid change at the same location from SARS-CoV to MERS-CoV and SARS-CoV to SARS-CoV-2. SARS-CoV: severe acute respiratory syndrome coronavirus, MERS-CoV: Middle East respiratory syndrome coronavirus, SARS-CoV-2: severe acute respiratory syndrome coronavirus 2, and RBD: receptor-binding domain.