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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: J Am Chem Soc. 2019 Aug 23;141(35):13762–13766. doi: 10.1021/jacs.9b06970

Figure 1.

Figure 1.

Loss of monomeric peptide signal and formation of Aβ1−40 ordered structures during pressure-jump NMR experiments. (A) Decay of Aβ40 HSQC intensity, recorded 9.8 s after jumping to 2.5 kbar, as a function of the number of high-pressure/low-pressure (10 s/ 5 s) cycles. The last time point corresponds to 24 h after the start of the pressure-jump NMR experiment. (B, C) TEM images of negatively stained samples harvested at atmospheric pressure after a single pressure cycle (B) or after 12,000 pressure cycles (C).