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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: J Med Chem. 2021 Nov 19;64(23):16922–16955. doi: 10.1021/acs.jmedchem.1c00409

Figure 30.

Figure 30.

Crystal structure of the covalent complex of 152 (MAC-5576) with SARS-CoV-2 Mpro (PDB ID 7JT0) through the acylation of Cys145 (a) and its corresponding 2D interaction diagram (b).