Table 1.

Classification of Current SARS-CoV-2 and SARS-CoV M^pro Inhibitors

class	subclass	ref
covalent	peptidomimetic ketone	26,34,35,38–40,106–112
	peptidomimetic nitrile-containing	43
	peptidomimetic aldehyde	45,48,49,51–53
	peptides with aldehyde bisulfite	50,65,113
	peptidomimetic michael acceptors	29,64,66,67,114–116
	nonpeptidomimetic covalent inhibitors	74–77,79,80,117
noncovalent	aryl boronic acid derivative	86
	istin based	87–89,118
	benzotriazole based	90
	anilide	91
	aldehyde	92
	symmetric peptide or molecule	78,93
	aromatic disulfide	98
	ketone	119
	others	4,81,82,94,97,100–102,120–155
metal conjugated		94,104,105