. Author manuscript; available in PMC: 2022 Aug 7.

Published in final edited form as: J Med Chem. 2021 Nov 19;64(23):16922–16955. doi: 10.1021/acs.jmedchem.1c00409

Table 2.

Number of the Silent Mutations (N_silent), Missense Mutations (N_missense), and Unique Single Mutations (N_total) on the M^pro, Binding Domain of M^pro, and Non-binding Domain of M^pro

location	N _silent	N _missense	N _total
M^pro	489	906	1395
binding domain	59	78	137
non-binding domain	430	828	1258