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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: J Med Chem. 2021 Nov 19;64(23):16922–16955. doi: 10.1021/acs.jmedchem.1c00409

Table 4.

Top 10 Missense Mutations in the Nonbinding Domain of Mproa

SNP protein mutation total frequency ratio
10319C→T   L89F 60078 0.03029
10323A→G   K90R 38117 0.01922
10097G→A   G15S   9695 0.00489
10833C→T   A260V   5068 0.00256
10376C→T   P108S   4837 0.00244
10667T→G   L205V   4135 0.00208
10193G→A   E47K   3947 0.00199
10195A→T   E47D   3880 0.00196
10277C→T   L75F   2985 0.00151
10533G→T   C160F   2904 0.00146
a

The frequency is the number of complete SARS-CoV-2 sequences that carry a specific mutation, and the ratio is defined by the frequency of a specific mutation over the total number of complete SARS-CoV-2 sequences.