Table 4.
Reported cases of ATDs-induced DIHS
| Study | Ozaki (2005) | Ye (2010) | Our study |
|---|---|---|---|
| Age | 50 years | 34 years | 24 years |
| Sex | Male | Female | Female |
| ATDs | MMI | PTU | PTU |
| Time of onset after ATDs | 1.5 months | 6 weeks | 3 weeks |
| Fever | Yes | Yes | Yes |
| Rash | Yes | Yes | Yes |
| Hematologic abnormality | |||
| Leucocytosis | Yes | NR | No |
| Atypical lymphocytosis | No | NR | Yes |
| Eosinophilia | NR | Yes | Yes |
| Liver abnormality | Yes | Yes | Yes |
| Other affected organs | Lung | NR | Kidney |
| Lymphademopathy | NR | Yes | Yes |
| HHV-6 detection | Yes | NR | No |
| Other virus detection | CMV | NR | No |
| Treatment | Corticosteroid | Corticosteroid | Corticosteroid, IVIG |
ATDs antithyroid drugs, DIHS drug-induced hypersensitivity syndrome, HHV-6 human herpes virus-6, IVIG intravenous immunoglobulin, MMI methimazole, NR not reported, PTU propylthiouracil