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. 2022 Aug 6;17:4. doi: 10.1186/s13008-022-00080-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — dGLYAT is necessary for Eiger-JNK pathway-induced invasive cell migration. Fluorescent micrographs of third instar larval wing discs are shown (a-e). Compared with the ptc > GFP control (a), ptc > Egr-induced cell migration and up-regulated MMP1 expression (b) were suppressed by dGLYAT mutation (c) or RNAi (e), but not by LacZ expression (d). f Statistic of number of migrated cells is shown (left to right: n = 10, n = 12, n = 10. n = 12, n = 16). g Statistic of number of MMP1 positive dots is shown (left to right: n = 10, n = 22, n = 26. n = 27, n = 25). t-test was used to compute P-values. **P < 0.01, ****P < 0.0001. Detailed genotypes: a ptc-Gal4 UAS-GFP/+, b ptc-Gal4 UAS-GFP UAS-Egr ^Regg1/+, c ptc-Gal4 UAS-GFP UAS-Egr^Regg1/dGLYAT^c02982, d ptc-Gal4 UAS-GFP UAS-Egr^Regg1/+; UAS-LacZ/+, e ptc-Gal4 UAS-GFP UAS-Egr^Regg1/+; UAS-dGLYAT-IR/+