Fig. 4.

HDAC3 miKO promotes long-term functional recovery after TBI. Adult male HDAC3 miKO mice and age- and sex-matched WT control mice were subjected to TBI induced by CCI or non-injury control procedures (baseline control). A–D Sensorimotor deficits were assessed in male mice before (Pre) and up to 35 days after injury by the body curl (A), adhesive removal (B), hanging wire (C), and foot fault (D) tests. n = 9 (baseline) or 13 (TBI) mice per group. E The Morris water maze test was performed to assess spatial learning and spatial memory in male mice at 29–34 days after injury. Mice in all groups had comparable swim speeds, suggesting similar gross locomotor functions. n = 6–7 (baseline) or 13 (TBI) mice per group. Shown are the mean ± SD. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 TBI vs. baseline. *p < 0.05, **p < 0.01, ***p < 0.001 HDAC3 miKO vs. WT after TBI. ns no significant difference