Table 3.
Genetic Loci Significantly Associated with 3 Phenotypic Indicators Related to Platelets Identified by the GWAS After Imputation Analysis
| Indicator | Gene | SNP ID | Chr | Position | Alleles | MA | MAF | Func | β | SE | p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PLT | FIGN, GRB14 | rs10180568 | 2 | 164191260 | G /A | G | 0.001 | Intergenic | 3.05 | 0.69 | 2.56E-06 |
| OR2H1, MAS1L | rs116973845 | 6 | 29469134 | T /C | T | 0.262 | Intergenic | 0.16 | 0.04 | 2.89E-06 | |
| FASTKD2, CPO | rs138214429 | 2 | 206904970 | C /T | C | 0.485 | Intergenic | 0.20 | 0.05 | 1.39E-06 | |
| PDW | CDC73 | rs140402302 | 1 | 193147821 | G /A | G | 0.014 | Intronic | 0.95 | 0.20 | 2.05E-06 |
| MPV | LINC01507, TLE1 | rs1333934 | 9 | 80320182 | C /A | C | 0.487 | Intergenic | 0.01 | 0.00 | 3.39E-06 |
Notes: p value < 5E-08 indicates that the candidate SNVs have genome-wide significance; p value < 5E-06 indicates that the candidate SNVs have suggestive genome-wide significance.
Abbreviations: PLT, platelet count; PDW, platelet distribution width; MPV, mean platelet volume; N, number.