Table 2.
COVID-19–Related Disease Severity Outcomes According to Presence or Absence of GI Symptoms (Nausea, Vomiting, Diarrhea)
| Outcomes, n (%) | Weighted overall cohort |
Weighted hospitalized cohort |
||||
|---|---|---|---|---|---|---|
| No GI symptoms (n = 188,788) | GI symptoms (n = 29,257) | P-value | No GI symptoms (n = 24,048) | GI symptoms (n = 8382) | P-value | |
| Primary composite (hospitalization, ICU, mechanical ventilation, death) | 32,196 (17.1) | 8475 (29.0) | <.001 | N/A | N/A | N/A |
| Secondary composite (mechanical ventilation, death) | 12,925 (6.8) | 2071 (7.1) | .192 | 5121 (21.3) | 1628 (19.4) | .001 |
| Component outcomes | ||||||
| Death | 11,298 (6.0) | 1670 (5.7) | .104 | 3912 (16.3) | 1228 (14.6) | .001 |
| Mechanical ventilation | 3540 (1.9) | 972 (3.3) | <.001 | 2833 (11.8) | 986 (11.8) | .956 |
| ICU admission | 8830 (4.7) | 2716 (9.3) | <.001 | 8558 (35.6) | 2946 (35.2) | .489 |
| Hospitalization | 24,606 (13.0) | 7885 (26.9) | <.001 | N/A | N/A | N/A |
| Unweighted overall cohort | Unweighted hospitalized cohort | |||||
| Primary composite (hospitalization, ICU, mechanical ventilation, death) | 31,815 (16.9) | 8885 (30.4) | <.001 | N/A | N/A | N/A |
| Secondary composite (mechanical ventilation, death) | 13,045 (6.9) | 2032 (6.9) | .834 | 5278 (21.9) | 1529 (18.2) | <.001 |
| Component outcomes | ||||||
| Death | 11,461 (6.1) | 1592 (5.4) | <.001 | 4089 (17.0) | 1126 (13.4) | <.001 |
| Mechanical ventilation | 3472 (1.8) | 1038 (3.5) | <.001 | 2840 (11.8) | 977 (11.7) | .721 |
| ICU admission | 8615 (4.6) | 2876 (9.8) | <.001 | 8615 (35.8) | 2876 (34.3) | .013 |
| Hospitalization | 24,048 (12.7) | 8382 (28.6) | <.001 | N/A | N/A | N/A |
ICU, intensive care unit; N/A, not available.