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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: Cell Rep. 2018 Apr 3;23(1):112–126. doi: 10.1016/j.celrep.2018.03.039

Figure 6. Synergy Between CDC25 Inhibitors and a WEE1 Inhibitor In Vitro and with the Mitochondrial Protein Translation Inhibitor, Tigecycline, In Vivo.

Figure 6.

(A and B) Combined CDC25 inhibitors (A) BN82002 or (B) NSC663284) plus CDK1 inhibitor (RO3306) show additive/antagonistic effects, whereas CDC25 plus the WEE1 inhibitor (MK-1775) are mostly synergistic in BT549 TNBC cells. Similar results obtained with MDA-MB-231 cells are shown in Figures S7B and S7C.

(C) Combination index calculated by CompuSyn software for the two CDC25 inhibitors plus CDK1 (blue) or the WEE1 (red) inhibitors in BT549 and MDA-MB-231.

See Figure S7D for details of each inhibitor and cell line.