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. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Nature. 2022 Apr 20;604(7907):714–722. doi: 10.1038/s41586-022-04640-1

Table 1 |.

Case information and number of neurons analysed in this study

Case ID Age (years) Sex Diagnosis PFC neurons (MDA-amplified) Hippocampus (HC) CA1 neurons (MDA-amplified) PFC neurons (PTA-amplified)
Younger neurotypical controls
1278 0.4 M Neurotypical 9 3
5817 0.6 M Neurotypical 4 3
4638 15.1 F Neurotypical 10
1465 17.5 M Neurotypical 24 4
5532 18.4 M Neurotypical 4
5559 19.8 F Neurotypical 5 3
4643 42.2 F Neurotypical 10
5087 44 M Neurotypical 4 5 3
936 49.2 F Neurotypical 3 3
73 5 19
Aged neurotypical controls
5451 57 F Neurotypical 5 5 3
5666 65 M Neurotypical 3
5943 69 M Neurotypical 5 5 3
5572 70 F Neurotypical 3
5840 75.3 M Neurotypical 3 5
5219 77 F Neurotypical 4
5171 79.2 M Neurotypical 13
5511 80.2 F Neurotypical 3
5657 82.2 M Neurotypical 10 5 3
5823 82.7 F Neurotypical 3 5 3
4976 104 F Neurotypical 5 5 3
51 30 21
Alzheimer’s disease
1353 57 F AD (Braak VI) 7 5 4
1647 59 F AD (Braak VI) 7 5 6
2208 69 F AD (Braak VI) 5 5 4
4556 70 F AD (Braak VI) 5 5
5222 80 F AD (Braak VI) 6 5
1456 81 M AD (Braak VI) 5 5 4
2207 83 M AD (Braak VI) 3
1995 89 F AD (Braak V) 8 4 4
1828 91 F AD (Braak VI) 5 9 4
48 43 29
Total 29 individuals 172 PFC-MDA neurons 78 HC-MDA neurons 69 PFC-PTA neurons
Total: 319 neurons