Table 1 |.
Case information and number of neurons analysed in this study
| Case ID | Age (years) | Sex | Diagnosis | PFC neurons (MDA-amplified) | Hippocampus (HC) CA1 neurons (MDA-amplified) | PFC neurons (PTA-amplified) |
|---|---|---|---|---|---|---|
| Younger neurotypical controls | ||||||
| 1278 | 0.4 | M | Neurotypical | 9 | − | 3 |
| 5817 | 0.6 | M | Neurotypical | 4 | − | 3 |
| 4638 | 15.1 | F | Neurotypical | 10 | − | − |
| 1465 | 17.5 | M | Neurotypical | 24 | − | 4 |
| 5532 | 18.4 | M | Neurotypical | 4 | − | − |
| 5559 | 19.8 | F | Neurotypical | 5 | − | 3 |
| 4643 | 42.2 | F | Neurotypical | 10 | − | − |
| 5087 | 44 | M | Neurotypical | 4 | 5 | 3 |
| 936 | 49.2 | F | Neurotypical | 3 | − | 3 |
| 73 | 5 | 19 | ||||
| Aged neurotypical controls | ||||||
| 5451 | 57 | F | Neurotypical | 5 | 5 | 3 |
| 5666 | 65 | M | Neurotypical | − | − | 3 |
| 5943 | 69 | M | Neurotypical | 5 | 5 | 3 |
| 5572 | 70 | F | Neurotypical | − | − | 3 |
| 5840 | 75.3 | M | Neurotypical | 3 | 5 | − |
| 5219 | 77 | F | Neurotypical | 4 | − | − |
| 5171 | 79.2 | M | Neurotypical | 13 | − | − |
| 5511 | 80.2 | F | Neurotypical | 3 | − | − |
| 5657 | 82.2 | M | Neurotypical | 10 | 5 | 3 |
| 5823 | 82.7 | F | Neurotypical | 3 | 5 | 3 |
| 4976 | 104 | F | Neurotypical | 5 | 5 | 3 |
| 51 | 30 | 21 | ||||
| Alzheimer’s disease | ||||||
| 1353 | 57 | F | AD (Braak VI) | 7 | 5 | 4 |
| 1647 | 59 | F | AD (Braak VI) | 7 | 5 | 6 |
| 2208 | 69 | F | AD (Braak VI) | 5 | 5 | 4 |
| 4556 | 70 | F | AD (Braak VI) | 5 | 5 | − |
| 5222 | 80 | F | AD (Braak VI) | 6 | 5 | − |
| 1456 | 81 | M | AD (Braak VI) | 5 | 5 | 4 |
| 2207 | 83 | M | AD (Braak VI) | − | − | 3 |
| 1995 | 89 | F | AD (Braak V) | 8 | 4 | 4 |
| 1828 | 91 | F | AD (Braak VI) | 5 | 9 | 4 |
| 48 | 43 | 29 | ||||
| Total | 29 individuals | 172 PFC-MDA neurons | 78 HC-MDA neurons | 69 PFC-PTA neurons | ||
| Total: 319 neurons | ||||||