Table 1.

The flow chart of the study

Age: 7–60 years’ old Tested RT-PCR-positive COVID-19 patients Hospitalized patients
Test: CBC, Ferritin, CRP, Chest X-ray, Oxygen saturation level First day: Admitted patient
Mild patient		Moderate patient
Oxygen saturation ≥94%		Oxygen saturation 88–93%
Any of the following common symptoms of COVID-19 such as fever, cough, sore throat, fatigue, mild dyspnea, anosmia, and diarrhea		Any of the following common symptoms of COVID-19 such as fever, cough, sore throat, fatigue, mild dyspnea, anosmia, and diarrhea
Standard of care (SOC)	SOC plus E. neriifolia	SOC	SOC plus E. neriifolia
Moderate-to-mature leaf of E. neriifoliaweighting from 8 to 10 g Chew two leaves and swallow the juice Dose: three times daily (8 hourly).		Moderate-to-mature leaf of E. neriifoliaLeaves weight 8–10 g for single dose Chew two leaves and swallow the juice Dose: Three times daily (8 hourly).
Test: CBC, Ferritin, CRP, Chest X-ray, Oxygen saturation level Day 7 and 14: Admit and Discharge patient
Hierarchical analysis: Mortality, hospital stay, need of oxygen and oxygen consumption, transition to severe COVID-19.
After discharge, follow-up was done either physically or over telephone for next 6 months to assess study outcomes, additional safety information, and adverse effects, if any.