Table 6.

Outcomes from SOC + Euphorbia neriifolia treatment for moderate COVID-19 patients (N = 60)

Variables	Day of admission (mean ± SD)	7 days after admission (mean ± SD)	14 days after admission (mean ± SD)	p-values (days:1, 7)	p-values (days: 7, 14)
RBS (mmol/L)	7.901 ± 2.900	5.145 ± 0.706	5.190 ± 0.600	0.0003**, 0.0005**	0.4047, 0.8094
WBC (K/µL)	8.624 ± 2.373	5.651 ± 0.77	5.123 ± 0.807	0.0001**, 0.0003**	0.0370*, 0.0741
Neutrophil (%)	68.333 ± 10.486	54.800 ± 7.720	48.267 ± 5.007	0.0002**, 0.0004**	0.0086**, 0.0171**
Lymphocytes (%)	30.933 ± 13.79	28.467 ± 5.263	30.067 ± 6.147	0.2539, 0.5078	0.2394, 0.4789
Monocyte (%)	3.400 ± 1.805	3.800 ± 1.014	3.267 ± 1.033	0.0167**, 0.0335*	0.0016**, 0.0032**
Eosinophil (%)	2.200 ± 1.373	2.200 ± 0.676	1.933 ± 0.884	0.5, 1	0.2063, 0.4125
RBC (million/dL)	4.950 ± 0.853	4.999 ± 0.514	4.695 ± 0.425	0.4131, 0.8262	0.0848, 0.1696
Hemoglobin (g/dL)	16.902 ± 14.268	12.647 ± 0.632	12.800 ± 0.785	0.1349, 0.2697	0.2432, 0.4863
Platelets (K/µL)	251.133 ± 71.06	244.467 ± 27.383	233.400 ± 53.097	0.3483, 0.6967	0.1989, 0.3978
S. Ferritin (ng/mL)	277.764 ± 275.372	116.067 ± 66.263	79.200 ± 47.531	0.118, 0.0236*	0.0085**0.0171**
CRP (mg/L)	29.443 ± 34.637	5.333 ± 2.059	3.600 ± 1.549	0.0077**, 0.0154**	0.0146**, 0.0292*
D-dimer (µg/mL)	0.548 ± 0.407	0.289 ± 0.111	0.202 ± 0.051	0.0074**, 0.0147*	0.0083**, 0.0223*
O2 saturation at room air (%) at day 1	91.533 ± 1.959	97.133 ± 1.457	96.600 ± 1.40	0.0000**, 0.0000**	0.0045**, 0.0032**

COVID-19, coronavirus disease in 2019; RBS, random blood sugar; WBC, white blood count; RBC, red blood cell; CRP, C-reactive protein; S. Ferritin, serum ferritin; SOC, standard of care, O₂, oxygen. Data are shown as mean ± standard deviation. Statistical significance was considered when p-value was <0.01 and <0.05 and shown as ^** and ^* mark, respectively. p value = normal value one tail and bold value two tail, calculate with 5% level of significance