Table 2.
Patient-reported outcomes by atopic dermatitis severity in France, Italy, and the UK
| Parameter | France | Italy | UK | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mod/Sev | Moderate | Severe | Mod/Sev | Moderate | Severe | Mod/Sev | Moderate | Severe | |
| Patients, N (%) | 69 (100) | 52 (75.4) | 17 (24.6) | 128 (100) | 109 (85.2) | 19 (14.8) | 64 (100) | 56 (87.5) | 8 (12.5) |
| POEM | |||||||||
| Mean (SD) | 12.6 (6.7) | 10.7 (5.7) | 18.4 (6.1) | 10.6 (6.3) | 10.3 (6.1) | 12.2 (7.3) | 13.1 (6.9) | 12.7 (6.9) | 16.1 (6.1) |
| Mean adjusteda (SE) | – | 10.8 (0.8) | 16.7 (1.5) | – | 10.2 (0.6) | 13.7 (1.5) | – | 12.3 (0.9) | 17.6 (1.1) |
| DLQIb | |||||||||
| Mean (SD) | 10.1 (6.3) | 8.5 (5.6) | 15.1 (5.9) | 9.5 (5.7) | 9.1 (5.4) | 12.0 (7.1) | 11.1 (5.6) | 10.0 (4.6) | 18.9 (6.3) |
| Mean adjusteda (SE) | – | 8.6 (0.8) | 13.0 (1.3) | – | 9.2 (0.5) | 13.7 (1.4) | – | 9.9 (0.6) | 18.4 (1.5) |
| EQ-5Db | |||||||||
| Mean (SD) | 0.74 (0.22) | 0.77 (0.20) | 0.70 (0.30) | 0.86 (0.12) | 0.88 (0.10) | 0.74 (0.16) | 0.89 (0.14) | 0.91 (0.13) | 0.77 (0.13) |
| Mean adjusteda (SE) | – | 0.77 (0.03) | 0.76 (0.06) | – | 0.87 (0.01) | 0.73 (0.05) | – | 0.91 (0.02) | 0.78 (0.03) |
| WPAI: % overall work impairment due to ADb | |||||||||
| Mean (SD) | 24.9 (26.7) | 20.5 (26.0) | 38.2 (25.5) | 20.2 (19.9) | 18.1 (17.6) | 29.8 (27.8) | 22.1 (21.9) | 18.2 (15.9) | 45.6 (38.1) |
| Mean adjusteda (SE) | – | 20.3 (4.6) | 35.0 (4.3) | – | 17.3 (2.9) | 58.0 (10.6) | – | 18.3 (2.8) | 64.3 (9.8) |
| WPAI: % activity impairment due to ADb | |||||||||
| Mean (SD) | 32.9 (26.2) | 26.0 (21.6) | 55.6 (27.6) | 31.5 (23.6) | 30.7 (23.2) | 35.8 (26.3) | 25.4 (18.1) | 22.8 (15.5) | 44.3 (25.1) |
| Mean adjusteda (SE) | – | 26.3 (3.0) | 49.2 (4.4) | – | 30.9 (2.2) | 32.6 (6.4) | – | 22.8 (2.2) | 43.9 (8.6) |
| WPAI: % work time missed owing to ADb | |||||||||
| Mean (SD) | 4.9 (10.3) | 5.1 (10.7) | 4.3 (9.7) | 2.4 (13.3) | 2.5 (14.6) | 2.3 (5.4) | 2.1 (9.8) | 0.1 (0.82) | 15.3 (25.5) |
| Mean adjusteda (SE) | – | 5.0 (1.9) | 1.3 (1.9) | – | 2.6 (2.3) | 2.6 (1.8) | – | 0.1 (0.1) | 25.5 (8.6) |
| WPAI: % impairment while working due to ADb | |||||||||
| Mean (SD) | 24.3 (25.9) | 18.1 (23.4) | 41.0 (26.0) | 21.2 (19.9) | 19.7 (18.7) | 27.8 (24.4) | 21.1 (21.5) | 17.4 (16.1) | 40.0 (35.2) |
| Mean adjusteda (SE) | – | 17.7 (4.1) | 32.6 (3.9) | – | 19.1 (3.0) | 35.2 (11.5) | – | 17.5 (2.8) | 42.3 (14.4) |
PRO data derived from patient self-completion forms on the basis of physician assessment of severity (n = 261)
AD atopic dermatitis, DLQI Dermatology Life Quality Index, Mod/Sev moderate or severe, POEM Patient-Oriented Eczema Measure, SD standard deviation, SE standard error, WPAI Work Productivity and Activity Impairment instrument
aMean values adjusted for confounders (age, sex, body mass index, and Charlson Comorbidity Index)
bNumber of patients was lower for these parameters in some or all countries and/or disease severity categories