Table 3.
Patient-reported outcomes for patients with moderate to severe atopic dermatitis by flare status in France, Italy, and the UK
| Parametera | France | Italy | UK | |||
|---|---|---|---|---|---|---|
| Not flaring | Currently flaring | Not flaring | Currently flaring | Not flaring | Currently flaring | |
| Number of patientsb | 27 | 31 | 54 | 54 | 32 | 20 |
| POEM | ||||||
| Mean (SD) | 10.4 (5.7) | 15.2 (6.9) | 7.7 (6.1) | 14.5 (5.9) | 11.3 (6.5) | 15.8 (6.5) |
| Mean adjustedc (SE) | 12.3 (1.2) | 13.9 (1.6) | 8.1 (0.8) | 14.1** (0.9) | 11.3 (1.1) | 13.9 (2.0) |
| POEM subscores (mean and SD) | ||||||
| Itch | 2.4 (1.3) | 3.1 (1.2) | 1.3 (1.2) | 2.8 (0.8) | 2.4 (1.2) | 3.3 (1.0) |
| Sleep | 1.1 (1.2) | 2.3 (1.4) | 1.0 (1.1) | 1.9 (1.2) | 2.0 (1.1) | 2.5 (1.4) |
| Bleeding | 0.6 (1.1) | 1.0 (1.3) | 0.7 (0.8) | 1.2 (1.2) | 0.8 (1.1) | 1.2 (1.5) |
| Weeping/oozing | 0.4 (0.7) | 1.2 (1.3) | 0.7 (0.9) | 1.4 (1.2) | 0.8 (1.0) | 1.0 (1.3) |
| Cracking | 1.5 (1.3) | 2.0 (1.5) | 1.4 (1.4) | 2.5 (1.2) | 1.2 (1.1) | 2.0 (1.5) |
| Flaking | 1.7 (1.3) | 2.3 (1.5) | 1.1 (1.1) | 2.1 (1.3) | 1.7 (1.4) | 2.4 (1.3) |
| Dry/rough | 2.6 (1.2) | 3.2 (1.1) | 1.4 (1.4) | 2.9 (1.2) | 2.4 (1.2) | 3.4 (0.9) |
| DLQI | ||||||
| Mean (SD) | 8.7 (5.6) | 11.8 (6.4) | 7.2 (6.0) | 11.5 (4.7) | 9.8 (3.9) | 12.8 (5.7) |
| Mean adjustedc (SE) | 10.2 (1.0) | 9.9 (1.1) | 7.5 (0.8) | 10.9* (0.7) | 9.7 (0.7) | 10.9 (2.1) |
| EQ-5D | ||||||
| Mean (SD) | 0.78 (0.22) | 0.69 (0.22) | 0.86 (0.12) | 0.83 (0.15) | 0.93 (0.10) | 0.85 (0.18) |
| Mean adjustedc (SE) | 0.72 (0.05) | 0.71 (0.04) | 0.86 (0.02) | 0.82 (0.03) | 0.93 (0.02) | 0.90 (0.04) |
| WPAI: % overall work impairment due to AD | ||||||
| Mean (SD) | 26.5 (29.4) | 29.9 (27.4) | 17.0 (17.8) | 28.1 (24.4) | 14.7 (14.1) | 32.6 (26.0) |
| Mean adjustedc (SE) | 37.5 (7.0) | 23.2 (10.1) | 21.1 (4.8) | 33.1 (6.8) | 15.1 (3.4) | 26.7 (5.0) |
| WPAI: % activity impairment due to AD | ||||||
| Mean (SD) | 29.3 (23.5) | 36.3 (27.9) | 23.0 (20.3) | 43.2 (24.3) | 23.3 (15.4) | 30.6 (14.7) |
| Mean adjustedc (SE) | 35.5 (4.4) | 29.0 (4.6) | 24.1 (3.0) | 43.7** (4.0) | 23.2 (2.9) | 26.5 (3.4) |
| WPAI: % work time missed owing to AD | ||||||
| Mean (SD) | 6.2 (12.2) | 5.6 (10.2) | 3.4 (17.5) | 2.2 (5.2) | 0.0 (0.0) | 4.5 (14.6) |
| Mean adjustedc (SE) | 9.7 (2.7) | 6.4 (3.5) | 4.7 (4.0) | 1.4 (1.0) | 0.0 (0.0) | 0.2 (0.3) |
| WPAI: % impairment while working due to AD | ||||||
| Mean (SD) | 24.0 (27.2) | 27.3 (24.9) | 18.7 (19.1) | 28.5 (21.9) | 14.7 (14.1) | 32.0 (26.0) |
| Mean adjustedc (SE) | 34.1 (6.8) | 19.0 (9.0) | 23.4 (4.7) | 33.3 (5.2) | 15.1 (3.4) | 26.1 (5.3) |
PRO data derived from patient self-completion forms on the basis of physician assessment of current flaring status
Results not reported by disease severity (moderate or severe) because of low patient numbers
DLQI Dermatology Life Quality Index, POEM Patient-Oriented Eczema Measure, PRO patient-reported outcome, SD standard deviation, SE standard error, WPAI Work Productivity and Activity Impairment instrument
*p < 0.01; **p< 0.0001 for the difference between flaring versus not flaring (Wald test)
aFor comparison of not flaring versus currently flaring for mean adjusted values only (t-test)
bNumber of patients was lower for all parameters in some or all countries and/or disease severity categories
cMean values for not flaring and flaring adjusted for confounders (age, sex, body mass index, Charlson Comorbidity Index, and severity)