TABLE 1.
Association between ZEBRA status and clinicopathological parameters in 64 nasopharyngeal carcinomas
| Value | ZEBRA status | ||
|---|---|---|---|
| Positive (n = 32) | Negative (n = 32) | p‐Value | |
| Age (years ± SD) * | 58.2 ± 13.6 | 59.0 ± 13.7 | 0.81 |
| Sex (%) | |||
| Male | 28 (88) | 26 (81) | 0.73 |
| Female | 4 (12) | 6 (19) | |
| Smoking (%) | |||
| Never | 9 (28) | 14 (43) | 0.30 |
| Past and present | 23 (72) | 18 (57) | |
| Alcohol (%) | |||
| Never | 20 (63) | 17 (53) | 0.61 |
| Past and present | 12 (37) | 15 (47) | |
| T (%) | |||
| 1–2 | 18 (56) | 15 (47) | 0.78 |
| 3–4 | 14 (44) | 17 (53) | |
| N (%) | |||
| 0–1 | 14 (44) | 18 (56) | 0.32 |
| 2–3 | 18 (56) | 14 (44) | |
| M (%) | |||
| 0 | 30 (94) | 30 (94) | 1 |
| 1 | 2 (6) | 2 (6) | |
| Stage (%) | |||
| I–II | 7 (22) | 8 (25) | 0.86 |
| III–IV | 25 (78) | 24 (75) | |
| WHO classification (%) | |||
| 2 | 20 (63) | 22 (69) | 0.79 |
| 3 | 12 (37) | 10 (31) | |
| Treatment (%) | |||
| CRT | 28 (88) | 30 (94) | 0.67 |
| RT | 3 (9) | 2 (6) | |
| Chemotherapy | 1 (3) | 0 (0) | |
| ERα (%) | |||
| Negative | 3 (9) | 27 (84) | <1 × 10 −8 |
| Positive | 29 (91) | 5 (16) | |
| Aromatase (%) | |||
| Negative | 10 (31) | 23 (72) | <0.01 |
| Positive | 22 (69) | 9 (28) | |
Note: The ZEBRA, ER⍺, and aromatase status was evaluated by immunohistochemistry (IHC), and the cutoff values were 15%, 10%, and 20%, respectively, determined from the median value of IHC of each positivity. All other values represent the number of cases and were evaluated cross‐table using the chi‐squared test. A p‐value <0.05 is considered significant and shown in boldface.
Abbreviations: CRT, chemoradiotherapy; ERα, estrogen receptor α; RT, radiotherapy; SD, standard deviation.
*
Data are presented as mean and SD and were evaluated by t‐test.