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. 2022 Jun 14;113(8):2888–2903. doi: 10.1111/cas.15402

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© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Overexpression of miR‐33a/b inhibited the stemness of DLBCL cells and enhanced their sensitivity to CHOP via PD‐L1. (A) Representative images of spheroids formed by transfected DLBCL cells. (B) The number of spheroids formed by transfected DLBCL cells. (C–F) Relative levels of OCT4 mRNA, Nanog mRNA, SOX2 mRNA, and ALDH1A1 mRNA in transfected DLBCL cells. (G, H) Flow cytometry analysis of the number of CD133‐positive cells following transfection. (I) Cell viability of transfected DLBCL cells upon CHOP treatment. (J, K) Percentage of apoptotic DLBCL cells following CHOP treatment