FIGURE 6.

Intervention mechanism of MgIG on CRIZO‐induced hepatotoxicity. In hepatocytes, CRIZO activates excessive production of ROS due to RCC I dysfunction and Nrf2 downregulation, which causes the dysregulation of autophagy and activation of inflammasomes. The NLRP3 inflammasome activates caspase‐1, in turn cleaves GSDMD into GSDMD‐N, which facilitates the formation of membrane pores, ultimately resulting in pyroptosis. MgIG protected mitochondria from CRIZO damage and re‐activated Nrf2/HO‐1 antioxidant pathway, thus reduced CRIZO‐induced ROS accumulation, which in turn inhibits CRIZO‐induced autophagy and pyroptosis of hepatocyte.