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. 2022 Jun 14;113(8):2681–2692. doi: 10.1111/cas.15387

FIGURE 2.

FIGURE 2

lncRNA XLOC013218 (XLOC) confers temozolomide (TMZ) resistance, facilitates cell proliferation, and inhibits cell apoptosis. A, TMZ sensitivity of U87 and U251 cells after V‐NC or V‐XLOC transfection. B, Cell viability of U87 and U251 V‐NC or V‐XLOC cells treated with TMZ (50 μg/ml) for 24, 48, 72, 96, and 120 h. C, TMZ sensitivity of U87TR and U251TR cells after sh‐NC or sh‐XLOC transfection. D, Cell viability of U87TR and U251TR sh‐NC or sh‐XLOC cells treated with TMZ (50 μg/ml) for 24, 48, 72, 96, and 120 h. E‐H, EdU cell proliferation assays (E) (scale bar, 50 μm), colony formation assay (F), and flow cytometric apoptosis assays (G, H) of XLOC‐overexpressed cells, XLOC‐knockdown cells, and their control cells. Data are presented as the mean ± SD of three independent experiments. *p < 0.05