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Therapeutic effect of BMP-2@Chi-MSN on bone defect. (a) Macroscopic appearance of lesions in saline, PLGA, or Chi-MSN-treated bone defect mice. (b) Trabecular number of lesions in saline, PLGA, or Chi-MSN-treated bone defect mice. (c) Trabecular thickness of lesions in saline, PLGA, or Chi-MSN-treated bone defect mice. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. control or PLGA group.
