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. 2022 Jul 25;13:921003. doi: 10.3389/fphar.2022.921003

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Copyright © 2022 Yang, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential mechanisms of resveratrol in relieving knee osteoarthritis. There are many molecular mechanisms involved in the occurrence and development of knee osteoarthritis. Resveratrol plays multiple positive roles in knee osteoarthritis, reducing inflammatory activation, cell apoptosis, maintaining cartilage homeostasis and promoting autophagy through several signal pathways. (A) Anti-inflammatory effects. (B) Anti-apoptotic/proliferous effects. (C) Anti-catabolic/Pro-anabolic effects. (D) Autophagy-promoting effects. ↑: up-regulation. ↓: down-regulation.