Table 2.
Relative mtDNA copy number across definitions of metabolic health based on 0 or 1 NCEP-ATPIII criteria, HOMA-IR < 2.5, the empirical definition by Zempic et al. and the metabolic syndrome.
| Metabolic health definition | Relative mtDNA copy number | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Median | Q75 | Q25 | p valuea | p valueb | p valuec | p valued | p value e | p value f | p value g | ||
| Metabolic health defined by 0 or 1 NCEP-ATPIII parameters | MHNW | 131 | 145.5 | 211.1 | 117.7 | <0.01 | <0.01 | NS | NS | <0.01 | <0.01 | – |
| MUHNW | 25 | 172.3 | 207.0 | 114.0 | ||||||||
| MHOW/O | 217 | 59.2 | 105.2 | 34.9 | ||||||||
| MUHOW/O | 148 | 76.0 | 133.0 | 35.4 | ||||||||
| Metabolic health defined by HOMA-IR < 2.5 | MHNW | 147 | 152.1 | 212.7 | 118.9 | <0.01 | <0.01 | NS | NS | NS | 0.018 | – |
| MUHNW | 7 | 125.0 | 199.6 | 107.4 | ||||||||
| MHOW/O | 270 | 59.9 | 110.2 | 36.4 | ||||||||
| MUHOW/O | 85 | 65.3 | 143.5 | 31.5 | ||||||||
| Metabolic health defined by Zembic et al | MHNW | 143 | 146.1 | 211.1 | 117.7 | <0.01 | <0.01 | NS | NS | <0.01 | <0.01 | – |
| MUHNW | 13 | 191.3 | 207.0 | 115.1 | ||||||||
| MHOW/O | 268 | 60.4 | 111.5 | 34.9 | ||||||||
| MUHOW/O | 97 | 67.2 | 137.3 | 37.1 | ||||||||
| Metabolic Syndrome | Absent | 433 | 105.2 | 160.1 | 53.2 | – | – | – | – | – | – | <0.01 |
| Present | 88 | 46.2 | 126.4 | 31.0 | ||||||||
p valuea MHNW vs MUHOW/O.
p valueb MHNW vs MHOW/O.
p valuec MHOW/O vs MUHOW/O.
p valued MHNW vs MUHNW.
p valuee MUHNW vs MUHOW/O.
p valuef MUHNW vs MHOW/O.
p valueg Metabolic syndrome vs No metabolic syndrome.
MHNW, Metabolically healthy normal weight; MUHNW, Metabolically unhealthy normal weight; MHOW/O, Metabolically healthy overweight/obese; MUHOW/O, Metabolically unhealthy overweight/obese; Q75, Upper quartile; Q25, lower quartile; NCEP-ATPIII, National Cholesterol Education Program – Adult Treatment Panel III; NS, not significant.