Table 3.
Results of age adjusted binary logistic regression analysis between mtDNA copy number and metabolic syndrome, its individual components, the metabolically unhealthy phenotype [based on the empirical definition by Zembic et al] and HOMA-IR ≥ 2.5.
| Overall | Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Dependent variable | OR | 95%CI | p-value | OR | 95%CI | p-value | OR | 95%CI | p-value |
| Metabolic syndrome | 1.05 | 1.02-1.09 | 0.002 | 1.04 | 1.01-1.09 | 0.040 | 1.06 | 1.01-1.12 | 0.011 |
| Increased triglycerides | 1.04 | 1.01-1.08 | 0.015 | 1.02 | 1.00-1.05 | 0.010 | 1.05 | 0.99-1.11 | 0.075 |
| Increased FPG | 1.02 | 1.00-1.05 | 0.094 | 1.02 | 0.98-1.06 | 0.258 | 1.02 | 0.98-1.06 | 0.287 |
| Hypertension | 1.02 | 1.00-1.04 | 0.102 | 1.03 | 0.99-1.07 | 0.111 | 1.01 | 0.99-1.04 | 0.113 |
| Increased waist circumference males | - | 1.01 | 0.97-1.05 | 0.561 | - | ||||
| Increased waist circumference females | - | - | 1.07 | 1.04-1.11 | 0.010 | ||||
| Reduced HDL-C males | - | 1.03 | 0.98-1.08 | 0.257 | - | ||||
| Reduced HDL-C females | - | - | 1.03 | 0.99-1.06 | 0.184 | ||||
| Metabolically unhealthy phenotype | 1.04 | 1.02-1.09 | 0.039 | 1.07 | 1.03-1.12 | 0.03 | 1.04 | 1.02-1.20 | 0.04 |
| HOMA-IR ≥2.5 | 1.03 | 1.01-1.07 | 0.029 | 1.01 | 0.97-1.06 | 0.060 | 1.06 | 1.01-1.10 | 0.016 |
Odds ratios are given for a ten-fold reduction in mtDNA copy number in the overall cohort and stratified by gender.