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. 2022 Jul 25;12:885236. doi: 10.3389/fonc.2022.885236

Table 4.

Clinicopathological features of patients based on EGFR/CD4 status.

Characteristics Total cases EGFR+ p-value Total cases EGFR- p-value
CD4+ CD4- CD4+ CD4-
Number of Cases 59 19 (32.2%) 40 (67.8%) 83 30 (36.14%) 53 (63.86%)
Sex
Male 34 11 (57.89%) 23 (57.5%) 0.98 48 19 (63.33%) 29 (54.72%) 0.45
Female 25 8 (42.11%) 17 (42.5%) 35 11 (36.67%) 24 (45.28%)
Average Age [ ± stdev]*
Male 34 52.27 ± 10.69 60.78 ± 13.35 48 59.74 ± 8.88 57.41 ± 10.63
Female 25 63.75 ± 23.44 68.59 ± 12.26 35 65 ± 24.11 67.71 ± 14.52
Smoking History
Active smoker 24 5 (26.32%) 19 (47.5%) 0.03 34 10 (34.48%) 27 (50.94%) 0.46
Never smoker 22 10 (52.63%) 12 (30%) 28 12 (41.38%) 16 (30.19%)
Quit < 10 Years 3 3 (15.79%) 0 (0%) 9 3 (10.34%) 6 (11.32%)
Quit > 10 Years 10 1 (5.26%) 9 (22.5%) 8 4 (13.79%) 4 (7.55%)
N/A 1
Tumor Site
Alveolar 9 3 (15.79%) 6 (15%) 0.03 14 4 (13.33%) 10 (18.87%) 0.04
Floor of mouth 11 0 (0%) 11 (27.5%) 21 3 (10%) 18 (33.96%)
Tongue 27 14 (73.68%) 13 (32.5%) 26 11 (36.67%) 15 (28.30%)
Other 12 2 (10.53%) 10 (25%) 22 12 (40%) 10 (18.87%)
T Stage
T1 22 10 (52.63%) 12 (30%) 0.02 21 9 (30%) 12 (22.64%) 0.76
T2 16 7 (36.84%) 9 (22.5%) 24 8 (26.67%) 16 (30.19%)
T3/T4 21 2 (10.53%) 19 (47.5%) 38 13 (43.33%) 25 (47.17%)
N Stage
N0 27 15 (78.94%) 12 (30%) 0.002 45 18 (60%) 27 (50.94%) 0.72
N1/2a 16 2 (10.53%) 14 (35%) 12 4 (13.33%) 8 (15.09%)
N2b/2c/3 16 2 (10.53%) 14 (35%) 26 8 (26.67%) 18 (33.96%)
Differentiation
Well 3 2 (11.11%) 1 (2.56%) 0.36 12 7 (23.33%) 5 (9.62%) 0.1
Moderate 38 12 (66.67%) 26 (66.67%) 50 14 (46.67%) 36 (69.23%)
Poor 16 4 (22.22%) 12 (30.77%) 20 9 (30%) 11 (21.15%)
N/A 2 1
Perineural invasion
Yes 35 9 (47.37%) 26 (65%) 0.20 37 11 (36.67%) 26 (49.06%) 0.28
No 24 10 (52.63%) 14 (35%) 46 19 (63.33%) 27 (50.94%)
Lymphovascular invasion
Yes 25 4 (21.05%) 21 (52.5%) 0.02 29 7 (23.33%) 22 (41.51%) 0.1
No 34 15 (78.95%) 19 (47.5%) 54 23 (76.67%) 31 (58.49%)
Bone invasion
Yes 15 1 (5.26%) 14 (35%) 0.01 29 9 (30%) 20 (37.74%) 0.48
No 44 18 (94.74%) 26 (65%) 54 21 (70%) 33 (62.26%)
Local recurrence
Yes 20 8 (42.11%) 12 (30%) 0.36 25 10 (33.33%) 15 (28.30%) 0.63
No 39 11 (57.89%) 28 (70%) 58 20 (66.67%) 38 (71.70%)

*Average age at diagnosis.