Table 1.
Compilation of pyroptosis-related genes.
| Gene function | Gene symbol | Gene name |
|---|---|---|
| Pyroptosis core components | GSDMA | gasdermin A |
| GSDMB | gasdermin B | |
| GSDMC | gasdermin C | |
| GSDMD | gasdermin D | |
| GSDME (DFNA5) | gasdermin E (DFNA5) | |
| IL-1β | interleukin 1 beta | |
| IL18 | interleukin 18 | |
| Genes with pyroptosis function or regulate the expression of PRGs | CASP1 | caspase-1 |
| CASP3 | caspase-3 | |
| CASP4 | caspase-4 | |
| CASP5 | caspase-5 | |
| CASP6 | caspase-6 | |
| CASP8 | caspase-8 | |
| GZMA | granzyme A | |
| GZMB | granzyme B | |
| HMGB1 | high mobility group box 1 | |
| GBP1 | guanylate binding protein 1 | |
| GBP2 | guanylate binding protein 2 | |
| GBP3 | guanylate binding protein 3 | |
| GBP4 | guanylate binding protein 4 | |
| GBP5 | guanylate binding protein 5 | |
| DDX3X | DEAD-box helicase 3 X-linked | |
| NAIP | NLR family apoptosis inhibitory protein | |
| SERPINB1 | serpin family B member 1 | |
| C-FLIP | cellular FADD-like interleukin-1β converting enzyme inhibitory protein TNF receptor superfamily member 21 | |
| TNFRSF21 | interferon regulatory factor 2 | |
| IRF2 | Z-DNA binding protein 1 | |
| ZBP1 | perforin 1 | |
| PRF1 | DExH-box helicase 9 | |
| DHX9 | guanylate binding protein 5 | |
| DFNB59 (PJVK) | DFNB59 (pejvakin) | |
| CTSG | cathepsin G | |
| APIP | APAF1 interacting protein | |
| Inflammasome | AIM2 | absent in melanoma 2 |
| NLRC4 | NLR family CARD domain containing 4 | |
| NLRP1 | NLR family pyrin domain containing 1 | |
| NLRP2 | NLR family pyrin domain containing 2 | |
| NLRP3 | NLR family pyrin domain containing 3 | |
| NLRP6 | NLR family pyrin domain containing 6 | |
| NLRP7 | NLR family pyrin domain containing 7 | |
| NLRP9 | NLR family pyrin domain containing 9 | |
| NLRP12 | NLR family pyrin domain containing 12 | |
| NLRX1 | NLR family member X1 | |
| NOD2 | nucleotide binding oligomerization domain containing 2 | |
| TLR4 | toll like receptor 4 | |
| MEFV (Pyrin) | MEFV innate immuity regulator (Pyrin) | |
| PYDC1 | pyrin domain containing 1 | |
| PYCARD | PYD and CARD domain containing | |
| CARD8 | caspase recruitment domain family member 8 | |
| CARD16 | caspase recruitment domain family member 16 | |
| CARD18 | caspase recruitment domain family member 18 |