Table 3.
Top 7 GO terms and top 3 KEGG pathway analyses for the differentially expressed PRGs.
| Pathway id | Category | Description | Count | Genes | P-value |
|---|---|---|---|---|---|
| GO:0061702 | CC | inflammasome complex | 5 | CASP4, PYCARD, CASP1, CARD8, NLRP3 | 3.36E-13 |
| GO:0034612 | BP | cysteine-type endopeptidase activity involved in apoptotic process |
8 | CASP4, TNFRSF21, PYCARD, CASP1, CASP3, GBP1, CARD8, GBP2 | 7.52E-12 |
| GO:0032611 | BP | interleukin-1 beta production | 6 | PYCARD, CASP1, TLR4, CARD8, NLRP3, GBP5 | 5.09E-11 |
| GO:0032612 | BP | interleukin-1 production | 6 | PYCARD, CASP1, TLR4, CARD8, NLRP3, GBP5 | 1.30E-10 |
| GO:0097153 | MF | cysteine-type endopeptidase activity involved in apoptotic process | 4 | CASP4, PYCARD, CASP1, CASP3 | 2.06E-10 |
| GO:0032731 | BP | positive regulation of interleukin-1 beta production | 5 | PYCARD, CASP1, TLR4, CARD8, NLRP3 | 2.43E-10 |
| GO:0071356 | BP | cellular response to tumor necrosis factor | 7 | CASP4, TNFRSF21, , CASP1, GBP1, CARD8, GBP2 | 3.46E-10 |
| hsa04621 | KEGG | NOD-like receptor signaling pathway | 9 | CASP4, PYCARD, CASP1, GBP1, TLR4, CARD8, NLRP3, GBP2, GBP5 | 8.37E-13 |
| hsa05133 | KEGG | Pertussis | 5 | PYCARD, CASP1, CASP3, TLR4, NLRP3 | 7.53E-08 |
| hsa05130 | KEGG | Pathogenic Escherichia coli infection | 6 | CASP4, PYCARD, CASP1, CASP3, TLR4, NLRP3 | 2.77E-07 |
*GO, Gene Ontology; KEGG, Kyoto Encyclopedia ofGenes and Genomes; PRGs, pyroptosis-related genes.