Table 1.
Clinical characteristics of 4 clusters of children with atopic dermatitis (AD) and comparison between clusters.
| A (Intrinsic) | B (Egg white only) | C (Multiple foods) | D (Inhalants) | P value (Cluster comparison) | |
|---|---|---|---|---|---|
| Subject number, n (%) | 71 (27.5%) | 28 (10.8%) | 68 (26.4%) | 91 (35.3%) | |
| Sex ratio (M:F) | 1.22:1 (39/32) | 2.11:1 (19/9) | 1.27:1 (38/30) | 1.02:1 (46/45) | 0.454 |
| Age at enrollment (years), mean (± standard deviation) | 3.3 (±3.4) | 1.4 (±1.1).633 0322+6 |
2.3 (±1.7) | 6.3 (±3.9) | <0.001 |
| Age at AD onset, n (%) | <0.001 | ||||
| <3 months | 25 (35.2%) | 13 (46.4%) | 21 (30.9%) | 20 (22.0%) | |
| 3–6 months | 22 (31.0%) | 11 (39.3%) | 21 (30.9%) | 20 (22.0%) | |
| 6–12 months | 5 (7.0%) | 2 (7.1%) | 15 (22.1%) | 11 (12.1%) | |
| >12 months | 19 (26.8%) | 2 (7.1%) | 11 (16.2%) | 40 (44.0%) | |
| 1st relative family history of allergic diseases, n (%) | 46 (64.8%) | 24 (85.7%) | 47 (69.1%) | 64 (70.3%) | 0.236 |
| Allergic comorbidities | |||||
| Asthma | 4 (5.6%) | 1 (3.6%) | 1 (1.5%) | 14 (15.4%) | 0.006 |
| Allergic rhinitis | 12 (16.9%) | 4 (14.3%) | 17 (25.0%) | 39 (42.9%) | <0.001 |
| Allergic conjunctivitis | 7 (9.9%) | 2 (7.1%) | 5 (7.4%) | 22 (24.2%) | 0.006 |
| Chronic urticaria | 5 (7.0%) | 0 (0.0%) | 4 (5.9%) | 5 (5.5%) | 0.907 |
| Food allergy | 13 (18.3%) | 17 (60.7%) | 49 (72.1%) | 51 (56.0%) | <0.001 |
| Health-related quality of life (0–30), median (range) | 5.0 (0–20) | 5.0 (0–24) | 5.5 (0–23) | 8.0 (0–25) | 0.028 |
| Total IgE (IU/ml), mean (± standard deviation) | 213.2 (±627.7) | 87.8 (±114.9) | 763.0 (±1368.2) | 694.7 (±891.2) | 0.006 |
| Previous treatment with systemic immunosuppressants | 7 (9.9%) | 0 (0.0%) | 4 (5.9%) | 13 (14.3%) | 0.201 |
| Skin infection in the last 1 year | 8 (11.3%) | 3 (10.7%) | 14 (20.6%) | 19 (20.9%) | 0.260 |