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. 2022 Jul 25;10:945149. doi: 10.3389/fbioe.2022.945149

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Copyright © 2022 Marzagalli, Pelizzoni, Fedi, Vitale, Fontana, Bruno, Poggi, Dondero, Aiello, Castriconi, Bottino and Scaglione.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Organ on chip platform for immune-tumor cells cross-talk. Representative scheme of the experiment: HTLA-230 cells were embedded in a 3D alginate scaffold and cultured above a microcirculation of NK cells, for 4 h.