Table 5.
Erythrocyte fatty acids at study entry and following 12-week intervention with LC n-3 PUFAs or corn oil in normal weight and individuals living with obesity.
| Week - 0 Fish oil | Week - 12 Fish oil | |||||||
|---|---|---|---|---|---|---|---|---|
| Fatty acid | Normal weight1 | Obese1 | P2 | Normal weight1 | P3 | Obese1 | P3 | P4 |
| 14:0 | 0.55 (0.41, 0.63) | 0.49 (0.45, 0.61) | 0.935 | 0.50 (0.47, 0.62) | 0.648 | 0.50 (0.45, 0.64) | 0.940 | 0.787 |
| 16:0 | 24.79 (24.04, 25.63) | 25.26 (24.52, 26.49) | 0.291 | 24.76 (24.06, 25.84) | 0.242 | 25.18 (23.57, 25.90) | 0.037 | 0.957 |
| 16:1n-7 | 0.77 (0.58, 1.05) | 1.03 (0.84, 1.21) | 0.035 | 0.77 (0.61, 0.99) | 0.116 | 0.92 (0.72, 1.18) | 0.086 | 0.110 |
| 18:0 | 13.22 (12.24, 13.84) | 12.71 (12.14, 13.48) | 0.482 | 12.93 (11.93, 13.52) | 0.055 | 12.72 12.19, 13.46) | 0.370 | 0.685 |
| 18:1n-9 | 17.96 (16.79, 18.45) | 17.72 (16.90, 18.95) | 0.646 | 17.12 (16.54, 17.79) | <0.001 | 17.01 (16.63, 17.68) | 0.002 | 0.808 |
| 18:1n-7 | 1.36 (1.27, 1.52) | 1.30 (1.16, 1.38) | 0.070 | 1.38 (1.30, 1.44) | 0.893 | 1.29 (1.21, 1.37) | 0.654 | 0.058 |
| 18:2n-6 | 15.80 (14.93, 18.37) | 15.26 (13.48, 16.29) | 0.045 | 15.14 (14.62, 15.87) | 0.007 | 15.52 (12.98, 16.02) | 0.351 | 0.766 |
| 18:3n-6 | 0.18 (0.15, 0.20) | 0.19 (0.13, 0.26) | 0.685 | 0.13 (0.09, 0.17) | <0.001 | 0.16 (0.12, 0.22) | 0.040 | 0.079 |
| 18:3n-3 | 0.33 (0.30, 0.45) | 0.36 (0.35, 0.46) | 0.137 | 0.35 (0.29, 0.43) | 0.819 | 0.45 (0.33, 0.55) | 0.279 | 0.045 |
| 20:0 | 0.11 (0.09, 0.15) | 0.10 (0.08, 0.13) | 0.105 | 0.10 (0.09, 0.14) | 0.519 | 0.10 (0.08, 0.13) | 0.681 | 0.317 |
| 20:1n-9 | 0.32 (0.27, 0.40) | 0.30 (0.25, 0.42) | 0.646 | 0.28 (0.24, 0.36) | 0.015 | 0.26 (0.21, 0.31) | 0.062 | 0.234 |
| 20:2n-6 | 0.27 (0.25, 0.29) | 0.26 (0.22, 0.28) | 0.117 | 0.25 (0.22, 0.26) | <0.001 | 0.22 (0.20, 0.26) | 0.019 | 0.130 |
| 20:3n-6 | 1.85 (1.50, 2.22) | 2.18 (1.88, 2.34) | 0.040 | 1.33 (1.09, 1.61) | <0.001 | 1.75 (1.53, 1.81) | <0.001 | 0.002 |
| 20:4n-6 | 14.05 (13.45, 15.14) | 14.20 (13.49, 14.70) | 0.850 | 11.69 (10.83, 12.97) | <0.001 | 12.33 (11.72, 13.10) | <0.001 | 0.387 |
| 20:4n-3 | 0.07 (0.06, 0.09) | 0.06 (0.06, 0.11) | 0.892 | 0.06 (0.05, 0.07) | 0.056 | 0.06 (0.06, 0.09) | 0.100 | 0.482 |
| 20:5n-3 | 0.83 (0.68, 1.13) | 1.15 (0.96, 1.24) | 0.007 | 3.18 (2.71, 3.95) | <0.001 | 3.01 (2.60, 3.27) | <0.001 | 0.194 |
| 22:5n-3 | 2.53 (1.85, 2.68) | 2.58 (2.12, 2.93) | 0.213 | 3.22 (2.90, 3.44) | <0.001 | 3.09 (2.71, 3.42) | <0.001 | 0.317 |
| 22:6n-3 | 4.19 (3.63, 5.18) | 4.63 (3.43, 5.55) | 0.465 | 6.13 (5.79, 6.42) | <0.001 | 6.15 (5.51, 6.63) | <0.001 | 0.829 |
| Week - 0 Corn oil | Week - 12 Corn oil | |||||||
| Fatty acid | Normal weight1 | Obese1 | P2 | Normal weight1 | P5 | Obese1 | P5 | P6 |
| 14:0 | 0.53 (0.44, 0.65) | 0.54 (0.48, 0.70) | 0.386 | 0.53 (0.48, 0.62) | 0.589 | 0.53 (0.47, 0.68) | 0.391 | 0.947 |
| 16:0 | 24.43 (23.90, 24.86) | 25.03 (24.34, 25.79) | 0.057 | 23.99 (23.21, 25.40) | 0.116 | 24.95 (24.48, 25.44) | 0.247 | 0.083 |
| 16:1n-7 | 0.80 (0.65, 0.94) | 091 (0.72, 1.37) | 0.117 | 0.79 (0.50, 1.03) | 0.793 | 1.02 (0.82, 1.25) | 0.478 | 0.026 |
| 18:0 | 13.28 (11.99, 13.94) | 12.87 (12.13, 13.31) | 0.205 | 13.25 (12.47, 13.91) | 0.987 | 12.79 (12.27, 13.38) | 0.737 | 0.243 |
| 18:1n-9 | 17.65 (17.08, 18.34) | 18.41 (17.07, 19.00) | 0.405 | 17.91 (16.63, 18.02) | 0.232 | 18.17 (17.35, 18.83) | 0.627 | 0.162 |
| 18:1n-7 | 1.37 (1.26, 1.52) | 1.29 (1.20, 1.50) | 0.505 | 1.36 (1.18, 1.44) | 0.080 | 1.30 (1.22, 1.39) | 0.654 | 0.894 |
| 18:2n-6 | 16.30 (15.21, 16.69) | 16.02 (14.34, 16.46) | 0.243 | 16.98 (16.10, 18.67) | 0.008 | 15.77 (14.77, 17.02) | 0.117 | 0.018 |
| 18:3n-6 | 0.20 (0.14, 0.22) | 0.21 (0.18, 0.24) | 0.182 | 0.19 (0.14, 0.25) | 0.062 | 0.22 (0.18, 0.28) | 0.191 | 0.334 |
| 18:3n-3 | 0.36 (0.30, 0.40) | 0.43 (0.38, 0.51) | 0.008 | 0.38 (0.32, 0.52) | 0.731 | 0.44 (0.38, 0.55) | 0.737 | 0.117 |
| 20:0 | 0.12 (0.10, 0.13) | 0.11 (0.08, 0.15) | 0.641 | 0.13 (0.10, 0.16) | 0.471 | 0.10 (0.08, 0.14) | 0.681 | 0.134 |
| 20:1n-9 | 0.34 (0.27, 0.39) | 0.33 (0.26, 0.45) | 0.947 | 0.32 (0.29, 0.48) | 0.295 | 0.28 (0.25, 0.37) | 0.156 | 0.152 |
| 20:2n-6 | 0.25 (0.23, 0.30) | 0.27 (0.24, 0.31) | 0.424 | 0.27 (0.25, 0.30) | 0.544 | 0.27 0.23, 0.31) | 0.940 | 0.790 |
| 20:3n-6 | 1.60 (1.38, 1.76) | 2.21 (1.98, 2.38) | <0.001 | 1.63 (1.40, 1.79) | 0.179 | 2.16 (1.99, 2.34) | 0.526 | 0.001 |
| 20:4n-6 | 14.34 (12.77, 15.13) | 13.36 (12.86, 14.91) | 0.386 | 13.90 (12.92, 14.62) | 0.085 | 13.47 (12.16, 14.67) | 0.232 | 0.594 |
| 20:4n-3 | 0.07 (0.06, 0.08) | 0.07 (0.05, 0.11) | 0.920 | 0.07 (0.06, 0.09) | 0.376 | 0.08 (0.06, 0.11) | 0.823 | 0.841 |
| 20:5n-3 | 1.03 (0.88, 1.45) | 1.07 (0.83, 1.15) | 0.641 | 0.87 (0.74, 1.22) | 0.422 | 1.04 (0.87, 1.18) | 0.601 | 0.617 |
| 22:5n-3 | 2.46 (2.24, 2.76) | 2.45 (2.22, 2.82) | 0.973 | 2.34 (2.02, 2.56) | 0.098 | 2.61 (2.22, 2.81) | 0.654 | 0.117 |
| 22:6n-3 | 4.96 (4.07, 5.58) | 3.95 (3.45, 4.98) | 0.049 | 4.81 (3.74, 5.49) | 0.342 | 4.09 (3.35, 4.95) | 0.911 | 0.162 |
1Median (25th, 75th percentile); 2P obtained from Mann-Whitney-U analysis by comparison of obese and normal weight at week-0, 3P obtained from Kruskal-Wallis analysis by comparison of week-0 and week-12 fish oil data within each BMI group, 4P obtained from Mann-Whitney-U analysis by comparison of obese and normal weight at week-12 post fish oil intervention, 5P obtained from Kruskal-Wallis analysis by comparison of week-0 and week-12 corn oil data within each BMI group, 6P obtained from Mann-Whitney-U analysis by comparison of obese and normal weight at week-12 post corn oil intervention.