Table 3. Subgroup analysis of pRNFL thickness according to the onset time of NAION.
| Subgroup | No. | Heterogeneity |
WMD (95%CI) | Overall effect |
||
| I 2 | P | Z | P | |||
| Onset time >3mo | ||||||
| Average | 4 | 0 | 0.869 | 0.58 (-3.12, 4.28) | 0.31 | 0.758 |
| Superior | 4 | 0 | 0.953 | -5.65 (-11.87, 0.57) | 1.78 | 0.075 |
| Inferior | 4 | 0 | 0.779 | 10.89 (3.97, 17.82) | 3.08 | 0.002 |
| Nasal | 4 | 42.5% | 0.157 | -2.28 (-5.47, 0.91) | 1.40 | 0.161 |
| Temporal | 4 | 0 | 0.996 | 0.53 (-3.46, 4.52) | 0.26 | 0.795 |
| Onset time >6mo | ||||||
| Average | 7 | 9.6% | 0.355 | 1.93 (-0.81, 4.68) | 1.38 | 0.167 |
| Superior | 5 | 76.6% | 0.002 | -6.55 (-16.58, 3.48) | 1.28 | 0.201 |
| Inferior | 5 | 1.7% | 0.397 | 11.20 (6.23, 16.18) | 4.42 | ≤0.001 |
| Nasal | 5 | 0 | 0.623 | -1.94 (-5.30, 1.41) | 1.14 | 0.256 |
| Temporal | 5 | 0 | 0.845 | -2.77 (-6.47, 0.94) | 1.46 | 0.143 |
pRNFL: Peripapillary retinal nerve fiber layer; NAION: Non-arteritic anterior ischemic optic neuropathy; SD-OCT: Spectral-domain optical coherence tomography; WMD: Weighted mean difference; CI: Confidence interval; I2: I-square heterogeneity statistic; Z: Z-statistic.