Table 3.
Efficacy of botulinum toxin type A injection.
| Parameters | Baseline | After treatment | p -value a |
|---|---|---|---|
| Headache profile | |||
| Frequency (days/month) | 17.8 ± 9.9 | 9.5 ± 10.1 | 0.001 |
| Severity (VAS, 1–10) | 6.8 ± 1.3 | 5.0 ± 2.6 | <0.001 |
| HIT-6 (6 questions, 78 points) | 65.0 ± 7.4 | 55.2 ± 8.8 | <0.001 |
| Severe headache (HIT-6 ≥ 60 points) | 17 (85%) | 7 (35%) | 0.002b |
| MIDAS (5 questions, days/3 month) | 53.3 ± 29.4 | 28.3 ± 30.3 | 0.001 |
| grade 1 (MIDAS score 0–5) | 0 (0%) | 8 (40%) | 0.002b |
| grade 2 (MIDAS score 6–10) | 0 (0%) | 2 (10%) | |
| grade 3 (MIDAS score 11–20) | 3 (15%) | 0 (0%) | |
| grade 4 (MIDAS score ≥21) | 17 (85%) | 10 (50%) | |
| MSQ (14 questions, 100 points) | 68.8 ± 47.1 | 105.0 ± 40.3 | <0.001 |
| MSQ_RR (7 questions) | 23.9 ± 15.0 | 36.1 ± 13.7 | 0.001 |
| MSQ_RP (4 questions) | 24.3 ± 15.8 | 34.5 ± 14.4 | 0.003 |
| MSQ_EF (3 questions) | 20.7 ± 18.1 | 34.3 ± 16.8 | 0.001 |
| Vestibular symptom profiles | |||
| Frequency (days/month) | 14.0 ± 5.0 | 8.5 ± 5.4 | <0.001 |
| Intensity (VAS-D, 0–10) | 6.0 ± 2.8 | 3.7 ± 2.7 | 0.001 |
| VSS (15 questions, 60 points) | 30.1 ± 10.5 | 18.2 ± 11.3 | <0.001 |
| DHI (25 questions, 100 points) | 52.4 ± 27.8 | 31.6 ± 22.9 | <0.001 |
| Physical (7 questions, 28 points) | 11.6 ± 6.6 | 7.9 ± 5.2 | 0.001 |
| Functional (9 questions, 36 points) | 20.1 ± 11.9 | 13.8 ± 10.5 | 0.015 |
| Emotional (9 questions, 36 points) | 19.2 ± 10.0 | 10.1 ± 9.0 | <0.001 |
| Depression and anxiety profile | |||
| BDI (21 questions, 63 points) | 23.9 ± 15.6 | 16.0 ± 11.0 | <0.001 |
| BAI (21 questions, 63 points) | 26.6 ± 14.7 | 16.7 ± 13.0 | 0.001 |
VAS, visual analog scale; HIT-6, Headache Impact Test-6; MIDAS, Migraine Disability Assessment; MSQ, Migraine Specific Quality of Life; RR, Role-function Restrictive; RP, Role-function Preventive; EF, Emotional Function; VAS-D, Visual Analog Scale-Dizziness; VSS, Vertigo Symptom Scale-short form; DHI, Dizziness Handicap Inventory; BDI, Beck Depression Inventory; BAI, Beck Anxiety Inventory.
a
Paired t-test;
b
Pearson's chi-square test.