TABLE 2.

Energy intake and physical activity between the two groups for 12 weeks.

	FO group		Placebo group		Adjusted difference of FO vs. placebo over 12 weeks	pa
	Baseline	12 week	Baseline	12 week
Intention to treat (n = 54)
Energy intake, Kcal/d	1527.2 ± 428.1	1968.7 ± 508.4	1495.1 ± 507.4	1433.1 ± 626.4	301.01 (−119.97, 722.13)	0.197
IPAQ, METs	1,215.0 [583.1−2,709.0]	1,278.0 [657.0−3,291.0]	1,825.0 [749.3−3445.3]	1,863.7 [693.0−3.666.0]	−	0.731
Per protocol (n = 49)
Energy intake, Kcal/d	1531.1 ± 436.1	1751.1 ± 403.5b	1515.4 ± 516.2	1558.8 ± 361.3	−240.28 (−537.65, 57.09)	0.111
IPAQ, METs	1,256.0 [600.0−2,772.0]	1,216.5 [657.0−3,291.0]	1,485.0 [618.8−3,443.3]	1,633.5 [693.0−3,465.0]	−	0.583

Values are median [IQR] or mean (95% CI) unless otherwise indicated. FO, Fermented Oyster Extract; IPAQ, international physical activity questionnaires; MET, metabolic equivalent task. ^aANCOVA or rank ANCOVA adjusted for age, sex, and each baseline value as covariates over the 12-week period. ^bP < 0.05 by paired t-test within each group.