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. 2022 Jul 25;16:917867. doi: 10.3389/fnins.2022.917867

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Copyright © 2022 Bhattacharjee, Purohit and Roy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell signaling pathways during mild and severe infections with SARS-COV2 and proposed therapeutic intervention of phytochemicals, tetracycline and cephalosporin ligands. (1) Mild infection with SARS-COV2, mainly lungs get affected, causing a high number of cytolytic T cells in the lungs. Phytochemicals act by targeting the T cells and monocytes, driving the cytokine storm in patients, leading to neuroinflammation. (2) Severe infection with SARS-COV2, affecting both lungs and the brain. Virus transmitting through a gustatory and olfactory nerve (tractography)-mediated route, causing neuroinflammation alleviated by Minocycline. Docking studies of phytochemicals, tetracycline and cephalosporin ligands, with the SARS-COV2 spike receptor-binding domain and main protease verify our approach.