Table 1.
Total number of retrieved targets from different databases.
| Category | Database | Number | Total number of unique targets | Number of common targets with disease | CytoNCA Predicted top 10 genes |
|---|---|---|---|---|---|
| Disease targets | |||||
| COVID19 | • UniProt • GeneCard • NCBI |
• 27 • 239 • 8 |
248 | ||
| JE | • UniProt • GeneCard • NCBI |
• 10 • 344 • 9 |
346 | ||
| Drug targets | • | • | |||
| Ceftriaxone | • GeneCard • DrugBank |
• 40 • 88 |
88 | 24 | IFNG, HLA-DRA, CXCL8, IL6, IL10RA, CD4, IL1R1, IL6ST, IL1B, TNF |
| Chlorogenic acid | • GeneCard • DrugBank |
• 25 • 43 |
68 | 11 | JUN, NFE2L2, MAFK, MTOR, NFE2, MAFG, HIF1A, NOS3, IL1B, ATP2B1 |
| Minocycline | • GeneCard • DrugBank |
• 91 • 46 |
136 | 39 | CCL5, CXCL8, CCL2, STAT1, IFNG, CCL18, CXCL9, CXCL10, CCR5, CCL4 |
| Naringenin | • GeneCard • DrugBank |
• 49 • 48 |
97 | 18 | TP53, STAT3, FAS, AKT1, STAT1, JUN, TNFRSF1A, FADD, CREBBP, FASLG |
| Podophyllotoxin | • GeneCard • DrugBank |
• 44 • 48 |
90 | 23 | STAT1, IRF2, IRF1, STAT3, IFNG, ITGB2, ICAM1, JUN, IRF9, IRF3 |
| Quercetin | • GeneCard • DrugBank |
• 183 • 48 |
226 | 79 | JUN, CXCL8, STAT1, IFNG, CCL2, STAT3, IRF1, CCL5, IL6, CXCL1 |