Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 25;16:831803. doi: 10.3389/fncel.2022.831803

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Maksymchuk, Sakurai, Cox and Cymbalyuk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of parameters determining kinetics of activation of the TRP current on the peak and the steady-state spiking rate of the CIII model’s responses to the fast temperature stimulation protocol. (A1) A representative example of the fast stimulation trace used in an experiment was applied to the CIII model. (A2,A3) Representative CIII model responses to this temperature protocol at different values of temperature of half activation: T_h = 281.5K and 290.5K, respectively. For convenience, Parameter T_h is represented by T_hC in ^oC, 8.35^oC, and 17.35^oC, respectively. (B1–D1) Color maps code spiking responses (x axis) of the CIII model to the stimulation trace (A1) using different values of the parameter of interest (y axis) with other parameters kept at their canonical values* (a canonical parameter set in Figure 7). In all color maps, the average frequency was calculated in the 2-s bin window. (B2–D2,B3–D3) Dependences of the spiking rate peak and the steady-state spiking rate, respectively, on the parameter values: temperature of half activation, T_h (T_hC is in ^oC, B), the steepness of TRP activation, A (C), and time constant of TRP activation, τ_mTRP (D). NR, no response.