Table 1.
Plasma metabolites related to amino acid metabolism in Lewis lung carcinoma-bearing wild-type (WT) and Mcp-1-/- mice fed the AIN93G or high-fat diet (HFD).
| AIN93G WT | AIN93G Mcp-1-/- | HFD WT | HFD Mcp-1-/- | Diet P | Gene P | Diet × Gene P | |
|---|---|---|---|---|---|---|---|
| N-acetylglycine | 1.00 ± 0.16 | 1.12 ± 0.22 | 1.03 ± 0.21 | 0.74 ± 0.15 | .34 | .64 | .28 |
| Alanine | 1.00 ± 0.07 | 0.89 ± 0.10 | 1.08 ± 0.07 | 1.14 ± 0.07 | .04 | .77 | .28 |
| Aminomalonate | 1.00 ± 0.09 | 1.20 ± 0.09 | 1.26 ± 0.09 | 1.10 ± 0.14 | .46 | .81 | .09 |
| Asparagine | 1.00 ± 0.10 | 0.95 ± 0.06 | 1.12 ± 0.07 | 1.15 ± 0.08 | .06 | .86 | .63 |
| Citrulline | 1.00 ± 0.05 | 0.94 ± 0.06 | 1.13 ± 0.05 | 1.02 ± 0.06 | .06 | .13 | .71 |
| Creatine | 1.00 ± 0.06 | 0.96 ± 0.10 | 1.03 ± 0.09 | 0.87 ± 0.15 | .75 | .32 | .54 |
| Creatinine | 1.00 ± 0.06 | 0.95 ± 0.09 | 1.07 ± 0.10 | 0.98 ± 0.13 | .60 | .46 | .85 |
| Cysteine | 1.00 ± 0.11 | 0.92 ± 0.14 | 1.26 ± 0.10 | 1.04 ± 0.12 | .12 | .21 | .56 |
| Cystine | 1.00 ± 0.20 | 1.04 ± 0.15 | 1.03 ± 0.09 | 1.07 ± 0.22 | .85 | .82 | .98 |
| Glutamic acid | 1.00 ± 0.11 | 1.04 ± 0.14 | 1.04 ± 0.09 | 0.99 ± 0.13 | .96 | .97 | .69 |
| Glutamine | 1.00 ± 0.12 | 1.17 ± 0.22 | 1.27 ± 0.15 | 1.09 ± 0.14 | .57 | .97 | .27 |
| Glycine | 1.00 ± 0.07 | 0.92 ± 0.09 | 1.12 ± 0.05 | 1.27 ± 0.12 | <.01 | .70 | .15 |
| Histidine | 1.00 ± 0.10 | 1.07 ± 0.12 | 1.14 ± 0.11 | 1.03 ± 0.12 | .68 | .89 | .43 |
| Indole-3-lactate | 1.00 ± 0.07 | 1.21 ± 0.11 | 1.29 ± 0.12 | 1.12 ± 0.07 | .30 | .87 | .06 |
| Isoleucine | 1.00 ± 0.05 | 0.92 ± 0.05 | 0.91 ± 0.05 | 0.78 ± 0.05 | .03 | .04 | .61 |
| Leucine | 1.00 ± 0.08 | 0.95 ± 0.04 | 0.92 ± 0.04 | 0.86 ± 0.05 | .15 | .33 | .95 |
| Lysine | 1.00 ± 0.09 | 1.15 ± 0.11 | 1.11 ± 0.11 | 1.10 ± 0.10 | .81 | .50 | .44 |
| Methionine | 1.00 ± 0.07 | 1.00 ± 0.09 | 1.20 ± 0.06 | 1.08 ± 0.09 | .08 | .41 | .45 |
| Methionine sulfoxide | 1.00 ± 0.08 | 0.99 ± 0.13 | 1.05 ± 0.07 | 1.00 ± 0.07 | .75 | .75 | .84 |
| Ornithine | 1.00 ± 0.08 | 1.04 ± 0.10 | 1.17 ± 0.11 | 1.11 ± 0.09 | .22 | .93 | .58 |
| Oxoproline | 1.00 ± 0.06 | 1.04 ± 0.04 | 1.08 ± 0.04 | 1.20 ± 0.06 | .03 | .14 | .46 |
| Phenylalanine | 1.00 ± 0.05 | 0.97 ± 0.04 | 0.97 ± 0.05 | 0.91 ± 0.03 | .28 | .33 | .73 |
| Proline | 1.00 ± 0.13 | 0.87 ± 0.17 | 1.39 ± 0.24 | 0.95 ± 0.24 | .25 | .17 | .46 |
| Serine | 1.00 ± 0.07 | 0.96 ± 0.11 | 1.18 ± 0.05 | 1.23 ± 0.04 | <.01 | .99 | .53 |
| Trans-4-hydroproline | 1.00 ± 0.06 | 1.02 ± 0.06 | 1.06 ± 0.05 | 1.20 ± 0.07 | .04 | .19 | .30 |
| Threonine | 1.00 ± 0.06 | 1.05 ± 0.12 | 1.24 ± 0.06 | 1.20 ± 0.10 | .02 | .98 | .60 |
| Tryptophan | 1.00 ± 0.11 | 1.08 ± 0.09 | 1.13 ± 0.09 | 1.06 ± 0.11 | .58 | .99 | .45 |
| Tyrosine | 1.00 ± 0.07 | 0.98 ± 0.10 | 1.15 ± 0.09 | 1.11 ± 0.10 | .13 | .76 | .90 |
| Urea | 1.00 ± 0.13 | 1.08 ± 0.17 | 1.02 ± 0.16 | 1.16 ± 0.17 | .74 | .49 | .85 |
| Valine | 1.00 ± 0.05 | 0.87 ± 0.03 | 0.93 ± 0.03 | 0.82 ± 0.05 | .18 | <.01 | .79 |
| 2-aminobutyric acid | 1.00 ± 0.09 | 1.00 ± 0.15 | 1.27 ± 0.08 | 1.07 ± 0.10 | .11 | .32 | .32 |
| 2-hydroxybutanoic acid | 1.00 ± 0.17 | 1.41 ± 0.35 | 0.94 ± 0.13 | 1.68 ± 0.56 | .74 | .08 | .60 |
| 2-ketoisocaproic acid | 1.00 ± 0.10 | 0.91 ± 0.08 | 1.00 ± 0.07 | 0.83 ± 0.06 | .64 | .11 | .65 |
Values of treatment groups are normalized to that of the AIN93G WT group. Values are means ± SEM with false discovery rate-adjusted P values (n = 12 per group for WT mice, n = 10 per group for Mcp-1-/- mice).