Figure 4.

Network of pDFIs for the top 20 drugs for which the most pDDIs were recorded. Grey dots stand for medications and blue dots represent other substances. The size of the grey dots shows the number of patients taking this drug (e.g. methylprednisolone was taken by 123 patients). The line colour indicates the severity of the interaction: green – mild interaction, yellow – moderate interaction and red – severe interaction. A total of 28 pDFIs were found between the top 20 drugs for which the most pDDIs were identified (Tables 3 and 5). Between those, there are 100 different pDDIs, which are not shown here for simplicity. A severe pDFI was found between ibuprofen and alcohol. Among the top 20 drugs, pantoprazole, torasemide, enoxaparin, hydrochlorothiazide and magnesium showed no interaction with alcohol, food or tobacco smoke.

pDDIs, potential drug–drug interactions; pDFIs, potential drug–food interactions.