Table 2.

Reduction of neutralization against VOCs and VUM by day-60 sera from high and moderate responders compared to those against wild-type Wuhan strain.

Strains	Wuhan	Alpha			Beta	Gamma	Delta	Kappa	E484K
	05-2N	QHN001	QK002	QHN002	TY8-612	TY7-501	K1734	K5356	F-76107	F-76137
(A) High responder’s sera (n = 15)
Average NT50	811 ± 155	351 ± 122	348 ± 88	287 ± 107	92 ± 53	283 ± 89	297 ± 108	147 ± 74	307 ± 133	504 ± 171
*Reduction (%)	–	56.7	57.1	64.6	88.7	65.1	63.4	81.9	62.1	37.9
p value vs 05-2N	–	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
(B) Moderate responder’s sera (n = 30)
Average NT50	301 ± 56	98 ± 40	128 ± 40	105 ± 41	53 ± 39	85 ± 29	122 ± 32	82 ± 38	121 ± 31	123 ± 38
*Reduction (%)	–	67.4	57.5	65.4	83.4	71.8	59.5	73.4	59.8	59.1
p value vs 05-2N	–	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

Average NT₅₀ titers of day-60 sera of high (n = 15) or moderate (n = 30) responders against SARS-CoV-2^05-2N and various variants are indicated.

*%Reduction of NT₅₀ titers compared to that against SARS-CoV-2^05-2N.